This paper presents a wirelessly powered closed-loop neuromodulation system, containing both implantable and wearable parts. The implantable part is an implantable neuromodulator tag that contains a customized application specific integrated circuit (ASIC) for neuro stimulation and recording, an off-the-shelf near field communication (NFC) proximity integrated circuit card (PICC) chip and one coupling coil for communication and power transferring. There are a wireless monitoring device, an NFC reader, electroencephalogram (EEG) electrodes and Near-infrared spectrum (NIRS) modules in wearable part. Intracranial neural recorder and wearable EEG/NIRS modules are able to provide multimodal biological information such as local field potentials (LFPs), EEG and cerebral tissue oxygen saturation (StO2) for algorithms to propose a more precise closed-loop stimulation strategy for better treatment effect. The ASIC chip is fabricated in a 0.18 μm CMOS technology. The stimulator has a limited size of 0.027mm2. Its stimulation current ranges from 0 to 0.6 mA with bandwidth of 10 Hz – 8 kHz, which is able to support precise neuromodulation. The recording channel features a bandwidth of 0.5 Hz to 100 Hz with a noise floor of 0.93 μVrms. The entire neuromodulator tag has a small footprint of 20 mm × 24 mm × 1.4 mm, and its weight is only 0.25 g.

本文提出了一种应用于成瘾性治疗的双闭环神经调控系统，其可兼容体外EEG、StO2监测和颅内LFP监测，结合离线数据分析与颅内刺激，分别构成常态化神经调控闭环回路和应急神经调控闭环回路，实现长期成瘾度的缓解和对突发药瘾的抑制。